Heterocyclic Communications p. 187 - 194 (2002)
Update date:2022-07-30
Topics:
El-Zohry, Maher F.
Al-Ahmadi, Abdullah A.
Aquily, Fatimah A.
2-Methyl-3,4-dihydroquinazolin-4-ones 1a,b reacted with cyclic ketones 2a-d in the presence of fused sodium acetate to yield 2-methinylcycloalkylidene-3H-quinazolin-4-one derivatives 3a-h. Quinazoline derivatives 3a-h reacted with hydrobromic acid in glacial acetic acid to give the bromo derivatives 4a-h. Compounds 4a-h reacted with ammonium carbonate and/or hexamethyl-enetetramine to afford 2-methylenylaminocycloalkane quinazoline derivatives 5a-h in good yields. Cyclization of 5a-h with acetic anhydride and acetic acid yielded the spiropyrimidoquinazoline derivatives 6a-h in excellent yields. All the synthesized quinazoline derivatives were identified by conventional methods (IR, 1H NMR) and elemental analyses.
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