Heterocyclic Communications p. 187 - 194 (2002)
Update date:2022-07-30
Topics:
El-Zohry, Maher F.
Al-Ahmadi, Abdullah A.
Aquily, Fatimah A.
2-Methyl-3,4-dihydroquinazolin-4-ones 1a,b reacted with cyclic ketones 2a-d in the presence of fused sodium acetate to yield 2-methinylcycloalkylidene-3H-quinazolin-4-one derivatives 3a-h. Quinazoline derivatives 3a-h reacted with hydrobromic acid in glacial acetic acid to give the bromo derivatives 4a-h. Compounds 4a-h reacted with ammonium carbonate and/or hexamethyl-enetetramine to afford 2-methylenylaminocycloalkane quinazoline derivatives 5a-h in good yields. Cyclization of 5a-h with acetic anhydride and acetic acid yielded the spiropyrimidoquinazoline derivatives 6a-h in excellent yields. All the synthesized quinazoline derivatives were identified by conventional methods (IR, 1H NMR) and elemental analyses.
View MoreSuzhou Sibian Chemical Technology Co., Ltd
website:http://www.sibianpharm.com
Contact:+8618169181984,+8618013186906
Address:Room1404,BuildingA,Jiabao Square No.323 Baodai East Road,Wuzhong District,Suzhou Jiangsu China (215128)
ANHUI CHEM-BRIGHT BIOENGINEERING CO.,LTD
Contact:86-561-4080321
Address:No.8 Lieshan Industrial Zone of Huaibei
Suzhou HeChuang Chemical Co.,Ltd.
Contact:+86-512-88800520
Address:No.9 Guanchao Rd,Changshu Advanced Materials Industy Park
Shanghai Yuking Water Soluble Material Tech Co., Ltd
Contact:86-21-68286299
Address:4F, 13B, No. 600, South Xinyuan Road 201306, Shanghai, China
Zhejiang Rongkai Chemical Technology Co.,Ltd.
Contact:+86-578-8185786
Address:Shangjiang Industrial Zone,Suichang
Doi:10.1021/ja028579j
(2003)Doi:10.1021/jm0400247
(2004)Doi:10.1055/s-2002-32543
(2002)Doi:10.1021/ja0208153
(2002)Doi:10.1016/j.molstruc.2019.02.056
(2019)Doi:10.1021/ja0176191
(2002)
