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Synthesis and antimicrobial evaluation of oxazole-1,4-naphthquinones

DOI: 10.1515/HC.2002.8.2.199

Source and publish data:

Heterocyclic Communications p. 199 - 204 (2002)

Update date:2022-08-03

Topics:

Authors:

De Oliveira, Claudia G. T.De Oliveira, Claudia G. T.

Ferreira, Vitor F.Ferreira, Vitor F.

Freitas, CiceroFreitas, Cicero

Carballido, Jupira M.Carballido, Jupira M.

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Article abstract of DOI:10.1515/HC.2002.8.2.199

Several routes for preparing oxazole nucleus fused to 1,4-naphthoquinone moiety were studied. Three new oxazole-1,4-naphthoquinone derivatives (4a-c) were prepared and evaluated against phatogenic bacteria. The use of ortho-ester methodology was found to be the best synthetic method for preparing these oxazoles, which showed very low antibacterial activity. The intermediate 2 showed a broad spectrum of activity comparable with oxacillin and vancomycin.

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Full text of DOI:10.1515/HC.2002.8.2.199

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Download Date | 5/31/15 7:42 AM  
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Download Date | 5/31/15 7:42 AM  
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Authenticated  
Download Date | 5/31/15 7:42 AM  
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Products guided by the article

Product name:2-benzoyl-3-nitroso-1,4-naphthoquinone

Cas No:474433-65-3

474433-65-3

R&D Labs maybe for 474433-65-3

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