Heterocyclic Communications p. 199 - 204 (2002)
Update date:2022-08-03
Topics:
De Oliveira, Claudia G. T.
Ferreira, Vitor F.
Freitas, Cicero
Carballido, Jupira M.
Several routes for preparing oxazole nucleus fused to 1,4-naphthoquinone moiety were studied. Three new oxazole-1,4-naphthoquinone derivatives (4a-c) were prepared and evaluated against phatogenic bacteria. The use of ortho-ester methodology was found to be the best synthetic method for preparing these oxazoles, which showed very low antibacterial activity. The intermediate 2 showed a broad spectrum of activity comparable with oxacillin and vancomycin.
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