Journal of Medicinal Chemistry p. 3197 - 3200 (2003)
Update date:2022-08-02
Topics:
Wu, Yong-Jin
Boissard, Christopher G.
Greco, Corinne
Gribkoff, Valentin K.
Harden, David G.
He, Huan
L'Heureux, Alexandre
Kang, Shing Hong
Kinney, Gene G.
Knox, Ronald J.
Natale, Joanne
Newton, Amy E.
Lehtinen-Oboma, Sanna
Sinz, Michael W.
Sivarao, Digavalli V.
Starrett Jr., John E.
Sun, Li-Qiang
Tertyshnikova, Svetlana
Thompson, Mark W.
Weaver, David
Wong, Henry S.
Zhang, Lei
Dworetzky, Steven I.
(S)-N-[1-(3-Morpholin-4-ylphenyl)ethyl]-3-phenyl-acrylamide (2) was synthesized as an orally bioavailable KCNQ2 potassium channel opener. In a rat model of migraine, 2 demonstrated significant oral activity in reducing the total number of cortical spreading depressions induced by potassium chloride.
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