Journal of Medicinal Chemistry p. 3197 - 3200 (2003)
Update date:2022-08-02
Topics:
Wu, Yong-Jin
Boissard, Christopher G.
Greco, Corinne
Gribkoff, Valentin K.
Harden, David G.
He, Huan
L'Heureux, Alexandre
Kang, Shing Hong
Kinney, Gene G.
Knox, Ronald J.
Natale, Joanne
Newton, Amy E.
Lehtinen-Oboma, Sanna
Sinz, Michael W.
Sivarao, Digavalli V.
Starrett Jr., John E.
Sun, Li-Qiang
Tertyshnikova, Svetlana
Thompson, Mark W.
Weaver, David
Wong, Henry S.
Zhang, Lei
Dworetzky, Steven I.
(S)-N-[1-(3-Morpholin-4-ylphenyl)ethyl]-3-phenyl-acrylamide (2) was synthesized as an orally bioavailable KCNQ2 potassium channel opener. In a rat model of migraine, 2 demonstrated significant oral activity in reducing the total number of cortical spreading depressions induced by potassium chloride.
View MoreGuangzhou Flower's Song Fine Chemical CO,. Ltd
Contact:+86-20-87475199
Address:No.12, Fenghuang 3 Road, Jiulong Industrial Park, Luogang District, Guangzhou. China
Xiamen Hisunny Chemical Co.,Ltd
website:http://www.hisunnychem.com
Contact:+86-592-3327115
Address:Unit 603,No.879,Xiahe Road,Meixin Building,Xiamen,China
Changsha Kamer Essence and Flavor Co.,Ltd
Contact:86-731-89832270
Address:No.327 Kangnin Road Changsha Bio Information Industry Park, Changsha city, Hunan province
Shanghai Coupling Pharmaceutical R&D Co., Ltd.(expird)
Contact:+86 021 50106671
Address:403 Room No.4 Buiding, No. 526 Ruiqing Road, Shanghai Zhangjiang Hi-Tech Park
Contact:86-21 60347964
Address:No.1304, West Meilong Road, Minhang District, Shanghai, China
Doi:10.1021/acs.orglett.1c01398
(2021)Doi:10.1002/hlca.19780610227
(1978)Doi:10.1039/a708373d
(1998)Doi:10.1080/07328303.2019.1709975
(2020)Doi:10.1021/jo01114a019
(1956)Doi:10.1016/S0040-4039(99)01443-4
(1999)