Critical modifications of the ISO-1 scaffold improve its potent inhibition of macrophage migration inhibitory factor (MIF) tautomerase activity

DOI: 10.1016/j.bmcl.2006.04.038

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3376 - 3379 (2006)

Update date:2022-09-26

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Authors:

Cheng, Kai Fan

Al-Abed, Yousef

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Article abstract of DOI:10.1016/j.bmcl.2006.04.038

Based on the scaffold of (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester (ISO-1), an inhibitor of the proinflammatory cytokine MIF, two critical modifications and chiral resolution have significantly improved the potency of the

Full text of DOI:10.1016/j.bmcl.2006.04.038

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