Asymmetric alkynylation of aldehydes catalyzed by an In(III)/BINOL complex

Article abstract of DOI:10.1021/ja053946n

Asymmetric alkynylation of both aromatic and aliphatic aldehydes using catalytic amounts of In(III)/BINOL is described. Dual activation of both substrates due to the "bifunctional character" of the indium(III) catalyst enables a broad range of substrate generality with high enantioselectivity (83 to > 99% ee). Copyright