Convergent synthesis of antiparallel cyclobolaphiles having two diacetylenes: Mimetics of membrane components that are found in archaea

Article abstract of DOI:10.1055/s-2002-33504

Chiral 48-membered antiparallel cyclobolaphiles and their diastereomer having two diacetylenes were convergently synthesized utilizing both cross-coupling method (Cul, pyrrolidine) and Glaser intramolecular cyclization, starting from commercially available D- and L-1, 2-O-isopropylidene-sn-glycerol as chiral sources.