Chemical Science p. 3757 - 3762 (2016)
Update date:2022-08-05
Topics: GC-MS Column chromatography Yield NMR spectroscopy Palladium-Catalyzed Anhydrous conditions Substrate Scope Catalyst Loading Aryl Iodides Reaction Optimization Triflates Inert atmosphere
Wu, Jiang
Liu, Yafei
Lu, Changhui
Shen, Qilong
A palladium-catalyzed difluoromethylthiolation of heteroaryl halides and triflates under mild conditions was described. A vast range of heteroaryl halides such as pyridyl, quinolinyl, benzothiazolyl, thiophenyl, carbazolyl and pyazolyl halides could be difluoromethylthiolated efficiently, thus providing medicinal chemists with new tools for their search of new lead compounds for drug discovery. Likewise, aryl iodides were difluoromethylthiolated in high yields under a modified reaction condition.
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