Synthesis of optically active N-(1-ethyl-3-methylhexahydro-1,3-diazin-5-yl)- and N-(1-ethyl-5-methyloctahydro-1,5-diazocin-3-yl)pyridine-3-carboxamides

Article abstract of DOI:10.1002/jhet.5570390417

As part of the structure-activity relationship of the dopamine D₂ and serotonin 5-HT₃ receptors antagonist 1, which is a clinical candidate with a broad antiemetic activity, the synthesis and dopamine D₂ and serotonin 5-HT