Synthesis and activity of 4,5-diarylimidazoles as human CB1 receptor inverse agonists

DOI: 10.1016/j.bmcl.2004.12.078

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1441 - 1446 (2005)

Update date:2022-08-04

Topics: Synthesis Inverse Agonists Activity

Authors:

Plummer, Christopher W.

Finke, Paul E.

Mills, Sander G.

Wang, Junying

Tong, Xinchun

Doss, George A.

Fong, Tung M.

Lao, Julie Z.

Schaeffer, Marie-Therese

Chen, Jing

Shen, Chun-Pyn

Stribling, D. Sloan

Shearman, Lauren P.

Strack, Alison M.

Van Der Ploeg, Lex H.T.

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Article abstract of DOI:10.1016/j.bmcl.2004.12.078

Structure-activity relationship studies directed toward the optimization of 4,5-diarylimidazole-2-carboxamide analogs as human CB1 receptor inverse agonists resulted in the discovery of the two amide derivatives 24a and b (hCB1 IC₅₀ = 6.1 and 4

Full text of DOI:10.1016/j.bmcl.2004.12.078

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