Optimization of monocarboxylate transporter 1 blockers through analysis and modulation of atropisomer interconversion properties

DOI: 10.1021/jm060995h

Source and publish data:

Journal of Medicinal Chemistry p. 254 - 263 (2007)

Update date:2022-08-04

Topics:

Authors:

Guile, Simon D.

Bantick, John R.

Cooper, Martin E.

Donald, David K.

Eyssade, Christine

Ingall, Anthony H.

Lewis, Richard J.

Martin, Barrie P.

Mohammed, Rukhsana T.

Potter, Timothy J.

Reynolds, Rachel H.

St-Gallay, Stephen A.

Wright, Andrew D.

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Article abstract of DOI:10.1021/jm060995h

We have previously described a novel series of potent blockers of the monocarboxylate transporter, MCT1, which show potent immunomodulatory activity in an assay measuring inhibition of PMA/ionomycin-induced human PBMC proliferation. However, the preferred

Full text of DOI:10.1021/jm060995h

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