Tetrahedron Asymmetry p. 1283 - 1294 (1995)
Update date:2022-09-26
Topics:
Camps, Pelayo
Farres, Xavier
Garcia, Luisa
Ginesta, Joan
Pascual, Jaume
et al.
Stereoselective syntheses of both enantiomers of ketoconazole (1) from commercially available (R)- or (S)-epichlorohydrin has been developed.The key-step of syntheses involves the selective substitution of the methylene chlorine atom by benzoate on a mixture of (2S,4R)-14a and (2R,4R)-15a or of their enentiomers, followed by crystalization of the corresponding cis-benzoates, (2R,4R)-18 or (2S,4S)-18, from which (+)- or (-)-1 were obtained as described for (+/-)-1.The ee's of (+)- and (-)-ketocanazole were determined by HPLC on the CSP Chiracel OD-H.
View MoreZhejiang Golden-Shell Pharmaceutical Co.,Ltd.
Contact:+86-576-87501888 / 87501988
Address:No.89 Zhongxing Road. Li'ao, Yuhuan, Zhejiang, China
Contact:+86-575-82733999 0575-82732999
Address:hangzhou gulf fine chemical zone,shangyu city,zhejiang province
SuZhou Hua-Emy Chemical Import and Export Co., LTD.
Contact:+86-512-88804994; +86-512-88804550;
Address:710, Building B, International Trade Center, 12 Huanghelu, Changshu, Jiangsu,China
website:http://www.greenutra.cn
Contact:0086-411-39553357
Address:No. 7-1-1802, Huizhi Garden,Ocean Square,Dalian, 116033, China
Anhui Xinyuan Technology Co.,Ltd
Contact:0086-559-3515800
Address:No.16 Zijin Rd, Circular Economic Zone, Huizhou District, Huangshan Anhui China
Doi:10.1021/jm020204l
(2003)Doi:10.1002/chem.201501557
(2015)Doi:10.1016/j.jcat.2019.12.002
(2020)Doi:10.1002/ejoc.201601204
(2017)Doi:10.1021/jm00269a008
(1973)Doi:10.1055/s-0030-1258533
(2010)
