Discovery and structure-activity relationship studies of N6-benzoyladenine derivatives as novel BRD4 inhibitors

DOI: 10.1016/j.bmc.2015.01.022

Source and publish data:

Bioorganic and Medicinal Chemistry p. 953 - 959 (2015)

Update date:2022-09-26

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Authors:

Noguchi-Yachide, Tomomi

Sakai, Taki

Hashimoto, Yuichi

Yamaguchi, Takao

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Article abstract of DOI:10.1016/j.bmc.2015.01.022

Bromodomain and extra-terminal domain (BET) proteins are epigenetic readers that bind to acetylated lysines in histones. Among them, BRD4 is a candidate target molecule of therapeutic agents for diverse diseases, including cancer and inflammatory disease.

Full text of DOI:10.1016/j.bmc.2015.01.022

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