Semisynthetic cephalosporins. Synthesis and structure activity relationships of 7 mandelamido 3 cephem 4 carboxylic acids

DOI: 10.1021/jm00247a008

Source and publish data:

Journal of Medicinal Chemistry p. 34 - 41 (1974)

Update date:2022-08-05

Topics: Synthesis Carboxylic Acids Semisynthetic cephalosporins Structure activity relationships Cephem

Authors:

Hoover Hoover

Dunn Dunn

Jakas Jakas

Lam Lam

Taggart Taggart

Guarini Guarini

Phillips

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Article abstract of DOI:10.1021/jm00247a008

The synthesis, microbiological profile, and in vivo effectiveness in laboratory animals of a broad spectrum cephalosporin, 7(R) mandelamidocephalosporanic acid (1), are described. A number of derivatives and analogs of 1 were prepared and their structure activity relationships are discussed.

Full text of DOI:10.1021/jm00247a008

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