Semisynthetic cephalosporins. Synthesis and structure activity relationships of 7 mandelamido 3 cephem 4 carboxylic acids

DOI: 10.1021/jm00247a008

Source and publish data:

Journal of Medicinal Chemistry p. 34 - 41 (1974)

Update date:2022-08-05

Topics: Synthesis Carboxylic Acids Semisynthetic cephalosporins Structure activity relationships Cephem

Authors:

Hoover Hoover

Dunn Dunn

Jakas Jakas

Lam Lam

Taggart Taggart

Guarini Guarini

Phillips

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00247a008

The synthesis, microbiological profile, and in vivo effectiveness in laboratory animals of a broad spectrum cephalosporin, 7(R) mandelamidocephalosporanic acid (1), are described. A number of derivatives and analogs of 1 were prepared and their structure activity relationships are discussed.

Full text of DOI:10.1021/jm00247a008

Products guided by the article

Product name:(6R)-3-acetoxymethyl-7t-[(R)-2-(2-chloro-phenyl)-2-hydroxy-acetylamino]-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; cyclohexylamine salt

Cas No:51359-35-4

R&D Labs maybe for 51359-35-4

JiYi Chemical (Beijing) Co., Ltd.

Contact:+86-10-89385733

Address:Shilou Town of Fangshan District， Beijing
LINAN HAIHUA CHEMICAL CO LTD

Contact:86-571-61063068

Address:LINAN
Guangzhou Puho Pharmaceutical Technology Co. Ltd.

Contact:86-20-29848035/29848075

Address:No.166, Chaoyang East Road, Panyu District, Guangzhou City, Guangdong Province
Guangzhou Flower's Song Fine Chemical CO,. Ltd

Contact:+86-20-87475199

Address:No.12, Fenghuang 3 Road, Jiulong Industrial Park, Luogang District, Guangzhou. China
Shanghai Yuanye Bio-Technology Co., Ltd.

website:http://www.shyuanye.com

Contact:+86-21-61845781

Address:Building 6, No. 465, Changta Road,Songjiang District,Shanghai,China

Relevant to this article

Doi:10.1021/jo01022a022
(1965)
Ultra-Short-Acting β-Adrenergic Receptor Blocking Agents. 3. Ethylenediamine Derivatives of (Aryloxy)propanolamines Having Esters on the Aryl Function

Doi:10.1021/jm00362a004
(1983)
Syntheses of β,β-difluorotryptamines

Doi:10.1021/jo020731c
(2003)
Paramagnetic organometallic molecules. 8. An ESR study of the redox chemistry of iron carbonyl species

Doi:10.1021/ic50204a037
(1980)
Synthesis of substituted uracils by the reactions of halouracils with selenium, sulfur, oxygen and nitrogen nucleophiles under focused microwave irradiation

Doi:10.1016/j.tet.2005.01.085
(2005)
Doi:10.1021/jo00932a019
(1974)

Article Doi