Journal of Medicinal Chemistry p. 34 - 41 (1974)
Update date:2022-08-05
Topics: Synthesis Carboxylic Acids Semisynthetic cephalosporins Structure activity relationships Mandelamido Cephem
Hoover
Dunn
Jakas
Lam
Taggart
Guarini
Phillips
The synthesis, microbiological profile, and in vivo effectiveness in laboratory animals of a broad spectrum cephalosporin, 7(R) mandelamidocephalosporanic acid (1), are described. A number of derivatives and analogs of 1 were prepared and their structure activity relationships are discussed.
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(1965)Doi:10.1021/jm00362a004
(1983)Doi:10.1021/jo020731c
(2003)Doi:10.1021/ic50204a037
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(1974)