R
SYNTHETIC COMMUNICATIONSV
11
The ester 2a is resistant to hydrolyzation because of the formation of a weak bond
between the O18 and C8 whereas the esters (3a–h) undergo hydrolyzation process to
produce mono and bis 1-aryl-1H-tetrazole-5-carboxylic acid. All the synthesized 16
compounds are characterized by IR, NMR and mass spectra. Future studies may stress
on the biological activities of the synthesized compounds.
Funding
One of the authors, S. Chandrakumari is thankful to UGC-Rajiv Gandhi National Fellowship
[RGNF-2017-18-SC-TAM-31743] for financial support.
References
[1] Hajduk, P. J.; Bures, M.; Praestgaard, J.; Fesik, S. W. Privileged Molecules for Protein
Binding Identified from NMR-Based Screening. J. Med. Chem. 2000, 43, 3443–3447. DOI:
[2] Bekhit, A. A.; El-Sayed, O. A.; Aboulmagd, E.; Park, J. Y. Tetrazolo[1,5-a]Quinoline as a
Potential Promising New Scaffold for the Synthesis of Novel anti-Inflammatory
and Antibacterial Agents. Eur. J. Med. Chem. 2004, 39, 249–255. DOI: 10.1016/
[3] Murali Krishna, S.; Padmalatha, Y.; Ravindranath, L. K. Tetrazoles as a Core Unit
Biological Evaluation Agent. Int. J. Med. Pharm. Res. 2015, 3, 1004–1010.
[4] Sidwell, R. W.; Huffman, J. H.; Khare, G. P.; Allen, L. B.; Witkowski, J. T.; Robins, R. K.
Broad-Spectrum anti-Viral Activity of Virazole: 1-beta-D-Ribofuranosyl-1,2,4-Triazole-3-
[5] Mohite, P. B.; Bhaskar, V. H. Potential Pharmacological Activities of Tetrazoles in the
New Millennium. Int. J. Pharmtech. Res. 2011, 3, 1557–1566.
[6] Hutchinson, D. W.; Naylor, M. The Antiviral Activity of Tetrazole Phosphonic Acids and
[7] Maxwell, J. R.; Wasdahl, D. A.; Wolfson, A. C.; Stenberg, V. I. Synthesis of 5-Aryl-2H-
Tetrazoles, 5-Aryl-2H-Tetrazole-2-Acetic Acids, and [(4-Phenyl-5-Aryl-4H-1,2,4-Triazol-3-
yl)Thio]Acetic Acids as Possible Superoxide Scavengers and Antiinflammatory Agents.
[8] Bhaskar, V. H.; Mohite, P. B. Design, Synthesis, Characterization and Biological
Evaluation of Some Novel 1,5-Disubstituted Tetrazole as Potential anti-Inflammator
Agents. J.Optoelectron. Biomed. Mater. 2010, 2, 231–237.
[9] Rajasekaran, A.; Thampi, P. P. Synthesis and Analgesic Evaluation of Some 5-[beta-(10-
phenothiazinyl)ethyl]-1-(acyl)-1,2,3,4-tetrazoles. Eur. J. Med. Chem. 2004, 39, 273–279.
[10] Maria Dorathi Anu, M.; Jayanthi, M.; Damodar Kumar, S.; Raja, S.; Thirunavukkarasu,
S. V. Synthesis, Characterization, Antibacterial & anti- Inflammatory Effects of Substituted
Tetrazole Derivatives Based on Different Types of Carbazone and Benzaldehyde. Int. J.
Chemtech. Res. 2013, 5, 1982–1990.
[11] Hayao, S.; Havera, H. J.; Strycker, W. G.; Leipzig, T. J.; Rodriguez, R. New
Antihypertensive Aminoalkyltetrazoles. J. Med. Chem. 1967, 10, 400–402. DOI: 10.1021/
[12] Abe, T.; Goto, T.; Hattori, Y.; Ito, S.; Kido, K.; Kurahashi, Y.; Maurer, F.; Otsu, Y.;
Sawada, H.; Shibuya, K.; et.al. 1-Phenyl-5-Anilinotetrazoles Derivatives, Their Preparation
and Their Use as Microbiocides, Insecticides and/or Herbicides. U.S. Patent 5,981,438.
1998.
[13] Le Bourdonnec, B.; Cauvin, C.; Meulon, E.; Yous, S.; Goossens, J. F.; Durant, F.; Houssin,
R.; Henichart, J. P. Comparison of 3D Structures and at(1) Binding Properities of