2-(Alkylthio)-1,2,4-triazolo[1,5-a]pyrimidines as adenosine cyclic 3',5'-monophosphate phosphodiesterase inhibitors with potential as new cardiovascular agents

DOI: 10.1021/jm00346a017

Source and publish data:

Journal of Medicinal Chemistry p. 420 - 426 (1982)

Update date:2022-08-05

Topics:

Authors:

Novinson

Springer

O'Brien O'Brien

Scholten

Miller Miller

Robins Robins

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Article abstract of DOI:10.1021/jm00346a017

A series of new 2-(alkylthio)-5,7-disubstituted-1,2,4-triazolo[1,5-a]pyrimidines have been prepared as inhibitors of cAMP phosphodiesterase from various tissues. These derivatives were prepared via ring closure of various requisite 3-amino-1,2,4-triazole

Full text of DOI:10.1021/jm00346a017

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