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9. Ohtani, I.; Kusumi, T.; Kashman, Y.; Kakisawa, H. J.
Arabidopsis
DHCR24 genes which encode proteins catalyzing the
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DIMINUTO/DWARF1
and
human
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1
10. Pertinent H NMR data for 11aR/S l: 0.642/0.664 (18-
-
H3), 0.835/0.899 (21-H3), 0.910/0.851, 0.905/0.835 (26-H3,
27-H3). For 11bR/S l: 0.662/0.638 (18-H3), 0.919/0.874
(21-H3), 0.854/0.916, 0.832/0.903 (26-H3, 27-H3).
sterols. Further, it has been reported that DHCR24
protein expressed in Saccharomyces cerevisiae belongs to
a family of FAD-dependent oxidoreductases (Waterham,
H. R.; Koster, J.; Romejin, G. J.; Hennekam, R. C. M.;
Vreken, P.; Andersson, H. C.; FitzPatrick, D. R.; Kelly,
R. I.; Wanders, R. J. A. Am. J. Hum. Genet. 2001, 69,
685–694; Klahre, U.; Noguchi, T.; Fujioka, S.; Takat-
suto, S.; Yokota, T.; Yoshida, S.; Chua, N. H. Plant Cell
1998, 10, 1677–1690). However, none of these studies
described purification of the reductase, although the
enzyme activity was found in a microsomal fraction.
11. Seo and co-workers noted the stereospecific hydrogen
attack at C-24 during cholesterol biosynthesis from [2-
13C,2-2H3]acetate in isolated dog hepatocytes, leaving the
orientation of the newly introduced hydrogen undeter-
mined: Seo, S.; Saito, H.; Uomori, A.; Yoshimura, Y.;
Tonda, K.; Nishibe, Y.; Hirata, M.; Takeuchi, Y.;
Takeda, K.; Noguchi, H.; Ebizuka, Y.; Sankawa, U.;
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