Journal of Medicinal Chemistry p. 1122 - 1126 (1980)
Update date:2022-07-29
Topics:
Tucker
The synthesis of a series (3-hydroxyprop-1-enyl)-substituted 1-(aryloxy)-3-(alkylamino)propan-2-ols is described. These compounds were investigated for their β-adrenoreceptor blocking properties and their selectivity of action. Among the o-(hydroxypropenyl)-substituted derivatives the authors have found some potent noncardioselective β-adrenoreceptor blocking agents which have a greater blocking action on the β2 receptor, thus resembling propanolol. The p-(hydroxypropenyl)-substituted analogues were generally less potent and tended to be cardioselective. The structure-activity relationships are discussed in the light of the hypothesis that the cardioselectivity of p-amido-substituted (aryloxy)propanolamines is attributable, in part, to binding of the amide group to some additional site on the β receptor; these findings argue against a similar interaction for the allylic hydroxyl group.
View Morejintan yufan Medicine Raw materials Co.,Ltd.(expird)
Contact:86-519-82808282
Address:6th,Jincheng Huangzhuang
shandong lukang animal & plant drug trading co.,ltd.
Contact:15853765968
Address:floor 9, lukang ,jingying building,#173,taibai building west road,jining city,shandong,china
Contact:0550-7041128 0550-7090578
Address:Wangdian Street,Xinjie Town
Dalian Join King Biochemical Tech. Co., Ltd.
Contact:0411 39216206
Address:814 First State Blvd
Jinan Decheng Hemu Medical Technology Co.,Ltd.
Contact:+86-531-68650525
Address:NO.554 Zhengfeng Road High-new Technology Development Zone
Doi:10.1021/jm00319a013
(1966)Doi:10.1002/jlcr.2580140211
(1978)Doi:10.1021/jo0101959
(2001)Doi:10.1016/0040-4020(73)80220-0
(1973)Doi:10.1021/acs.joc.0c00087
(2020)Doi:10.3184/174751912X13466926675198
(2012)