Journal of Medicinal Chemistry p. 1122 - 1126 (1980)
Update date:2022-07-29
Topics:
Tucker
The synthesis of a series (3-hydroxyprop-1-enyl)-substituted 1-(aryloxy)-3-(alkylamino)propan-2-ols is described. These compounds were investigated for their β-adrenoreceptor blocking properties and their selectivity of action. Among the o-(hydroxypropenyl)-substituted derivatives the authors have found some potent noncardioselective β-adrenoreceptor blocking agents which have a greater blocking action on the β2 receptor, thus resembling propanolol. The p-(hydroxypropenyl)-substituted analogues were generally less potent and tended to be cardioselective. The structure-activity relationships are discussed in the light of the hypothesis that the cardioselectivity of p-amido-substituted (aryloxy)propanolamines is attributable, in part, to binding of the amide group to some additional site on the β receptor; these findings argue against a similar interaction for the allylic hydroxyl group.
View Moretaicang liyuan chemical co,.ltd
website:http://www.tcliyuanchem.com/productse.php
Contact:86-512-53539583
Address:Room 804,Huaxu Building,No.95,Renmin South Road,Taicang city,Jiangsu Province,China
website:http://www.debyesci.com
Contact:+85221376140
Address:Rm. 19C, Lockhart Ctr., 301-307 Lockhart Rd., Wan Chai
Tai zhou world Pharm & Chem Co., Ltd
Contact:+86-576-85301198
Address:Rome 1001,wangjiang plaza,unti 2,jinshan east Road linhai,zhejiang,china
Jiangsu Wanlong Chemical Co., Ltd.
website:http://www.wanlongchem.com
Contact:+86-511-86810993 0086-511-8681 0888;
Address:Quanzhou Town, Danyang City, Jiangsu
Shanghai shibo Chemical Co., Ltd
Contact:+86-021-60753516
Address:688 Qiushi Road, Jinshan High-tech Park, Shanghai, China,201512
Doi:10.1021/jm00319a013
(1966)Doi:10.1002/jlcr.2580140211
(1978)Doi:10.1021/jo0101959
(2001)Doi:10.1016/0040-4020(73)80220-0
(1973)Doi:10.1021/acs.joc.0c00087
(2020)Doi:10.3184/174751912X13466926675198
(2012)