THE CONDENSATION REACTION BETWEEN ISOCYANATES AND CARBOXYLIC ACIDS. A PRACTICAL SYNTHESIS OF SUBSTITUTED AMIDES AND ANILIDES.

Article abstract of DOI:10.1016/S0040-4039(00)84230-6

Addition of a carboxylic acid to an isocyanate initially yields the mixed acid anhydride, decarboxylation of which leads to the N-substituted amide.The conversion of acid into amide was shown to proceed similarly for both aliphatic and aromatic carboxylic acids with a range of substituted isocyanates.