Tetrahedron Letters p. 1251 - 1254 (1986)
Update date:2022-07-31
Topics:
Blagbrough, Ian S.
Mackenzie, Neil E.
Ortiz, Claudio
Scott, A. Ian
Addition of a carboxylic acid to an isocyanate initially yields the mixed acid anhydride, decarboxylation of which leads to the N-substituted amide.The conversion of acid into amide was shown to proceed similarly for both aliphatic and aromatic carboxylic acids with a range of substituted isocyanates.
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