Journal of Medicinal Chemistry p. 1025 - 1027 (1974)
Update date:2022-08-05
Topics:
Coburn
Glennon
Chmielewicz
The discovery of in vitro antibacterial activity of mesoionic thiazolo[3,2-αDpyrimidine-5,7-diones and mesoionic 1,3,4-thiadiazolo[3,2-α]pyrimidine-5,7-diones has been recently reported. These compounds are members of a large, virtually unknown, class of mesoionic structures, termed mesoionic purinone analogs, which are isoelectronic and isosteric to the purinones: xanthine, hypoxanthine, or purin-2-one. The formulation, classification, and quantum chemical study of a large number of these heterocyclic structures have been described. A series of alkyl and aryl substituted mesoionic 1,3,4-thiadiazolo[3,2-α]pyrimidine-5,7-diones, mesoionic xanthine analogs, was prepared and examined for antibacterial activity in order to develop structure activity relationships leading to more active derivatives.
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Doi:10.1021/acs.jmedchem.8b01869
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(1974)Doi:10.1016/S0040-4020(03)00135-2
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