Journal of Medicinal Chemistry p. 4401 - 4410 (2019)
Update date:2022-08-05
Topics:
Riggs, Jennifer R.
Elsner, Jan
Cashion, Dan
Robinson, Dale
Tehrani, Lida
Nagy, Mark
Fultz, Kimberly E.
Krishna Narla, Rama
Peng, Xiaohui
Tran, Tam
Kulkarni, Ashutosh
Bahmanyar, Sogole
Condroski, Kevin
Pagarigan, Barbra
Fenalti, Gustavo
Lebrun, Laurie
Leftheris, Katerina
Zhu, Dan
Boylan, John F.
Triple negative breast cancer (TNBC) is an aggressive disease with high relapse rates and few treatment options. Outlined in previous publications, we identified a series of potent, dual TTK/CLK2 inhibitors with strong efficacy in TNBC xenograft models. P
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