Mechanism-based design of simple, symmetrical, easily prepared, potent antimalarial endoperoxides

DOI: 10.1016/0040-4039(95)02329-1

Source and publish data:

Tetrahedron Letters p. 815 - 818 (1996)

Update date:2022-08-05

Topics:

Authors:

Posner, Gary H.

Wang, Dasong

Gonzalez, Lluisa

Tao, Xueliang

Cumming, Jared N.

Klinedinst, Donna

Shapiro, Theresa A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(95)02329-1

Mechanism-based design, two-step synthesis, and in vitro antimalarial testing showed thermally stable, crystalline, bicyclic endoperoxides 2a and 2b to be potent antimalarials. Their reduction by FeBr₂ proceeds via oxy-radicals and then carbon

Full text of DOI:10.1016/0040-4039(95)02329-1

Products guided by the article

Product name:Benzene, 1,1'-[oxybis(1-methylene-2,1-ethanediyl)]bis-

Cas No:53891-28-4

R&D Labs maybe for 53891-28-4

Shanghai FWD Chemicals ltd

website:http://www.fwdchem.com

Contact:86-21-54450828

Address:Room 802,Lotus Tower ,159 Tianzhou Road,Xuhui District,Shanghai
Suzhou Jingye Medicine & Chemical Co., Ltd

Contact:+86-512-66658588

Address:No. 88, Sanlian Street, Jinfeng Road, Suzhou New District, Jiangsu Province, P. R. China
Hangzhou Kai Peng Biotechnology Co., Ltd.

Contact:86-571-89939007

Address:NO. 499, Wensan West Road, Xihu District, Hangzhou, 310012, China
Qingdao Kylin Trading Co., Ltd.

Contact:0086-532-68979884/58972912/68972263/65/88171519

Address:Room 2308,A building International Trade Center No.230 Changjiang Middle Road of Qingdao Economic Development Zone,Shandong,China.
Nanjing Fubang Chemical Co.,Ltd

Contact:+86-25-83179199

Address:5F,Tianzheng international plaza,No399 Zhongyang Road ,Nanjing China

Relevant to this article

Synthesis and analgesic activity of some acetamide derivatives

Doi:10.3109/14756366.2011.587417
(2012)
Catalysis of Cross-Coupling and Homocoupling Reactions of Aryl Halides Utilizing Ni(0), Ni(I), and Ni(II) Precursors; Ni(0) Compounds as the Probable Catalytic Species but Ni(I) Compounds as Intermediates and Products

Doi:10.1021/acs.organomet.7b00446
(2017)
Doi:10.1039/jr9550001834
(1955)
A NOVEL ROUTE TO SUBSTITUTED PHOSPHONATES VIA CONJUGATE ADDITION OF ORGANOMETALLICS TO 1-(FUNCTIONALLY) SUBSTITUTED ALKENE PHOSPHONATES.

Doi:10.1016/S0040-4039(01)81440-4
(1984)
Doi:10.1021/jo01110a024
(1956)
INFLUENCE OF A SILYL GROUP ON AN ALLYLIC POSITION. A THEORETICAL APPROACH

Doi:10.1016/0040-4020(80)80114-1
(1980)

Article Doi