Tetrahedron Letters p. 815 - 818 (1996)
Update date:2022-08-05
Topics:
Posner, Gary H.
Wang, Dasong
Gonzalez, Lluisa
Tao, Xueliang
Cumming, Jared N.
Klinedinst, Donna
Shapiro, Theresa A.
Mechanism-based design, two-step synthesis, and in vitro antimalarial testing showed thermally stable, crystalline, bicyclic endoperoxides 2a and 2b to be potent antimalarials. Their reduction by FeBr2 proceeds via oxy-radicals and then carbon
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