Mechanism-based design of simple, symmetrical, easily prepared, potent antimalarial endoperoxides

DOI: 10.1016/0040-4039(95)02329-1

Source and publish data:

Tetrahedron Letters p. 815 - 818 (1996)

Update date:2022-08-05

Topics:

Authors:

Posner, Gary H.

Wang, Dasong

Gonzalez, Lluisa

Tao, Xueliang

Cumming, Jared N.

Klinedinst, Donna

Shapiro, Theresa A.

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Article abstract of DOI:10.1016/0040-4039(95)02329-1

Mechanism-based design, two-step synthesis, and in vitro antimalarial testing showed thermally stable, crystalline, bicyclic endoperoxides 2a and 2b to be potent antimalarials. Their reduction by FeBr₂ proceeds via oxy-radicals and then carbon

Full text of DOI:10.1016/0040-4039(95)02329-1

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