Mechanism-based design of simple, symmetrical, easily prepared, potent antimalarial endoperoxides

DOI: 10.1016/0040-4039(95)02329-1

Source and publish data:

Tetrahedron Letters p. 815 - 818 (1996)

Update date:2022-08-05

Topics:

Authors:

Posner, Gary H.

Wang, Dasong

Gonzalez, Lluisa

Tao, Xueliang

Cumming, Jared N.

Klinedinst, Donna

Shapiro, Theresa A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(95)02329-1

Mechanism-based design, two-step synthesis, and in vitro antimalarial testing showed thermally stable, crystalline, bicyclic endoperoxides 2a and 2b to be potent antimalarials. Their reduction by FeBr₂ proceeds via oxy-radicals and then carbon

Full text of DOI:10.1016/0040-4039(95)02329-1

Products guided by the article

Product name:Benzene, 1,1'-[oxybis(1-methylene-2,1-ethanediyl)]bis-

Cas No:53891-28-4

R&D Labs maybe for 53891-28-4

SHANGHAI BIOSUNDRUG CO.,LTD.

Contact:86-21-34622192，13917187091，21-34622765

Address:No. 500 Caobao Road Shanghai P.R China
FOSHAN NANHAI ZHONGNAN PHARMACEUTICAL FACTORY

Contact:0086-0757-85609331

Address:XIAHENGTIAN INDUSTRIAL ZONE,SHAYONG VILLAGE,LISHUI TOWN
HAORUI ENTERPRISES LLC

Contact:(1) 206-3550089

Address:5115 NE 8TH PL, Renton, WA 98059 USA
Nanjing Chemical Material Corp.(NCMC)

website:http://www.njchemm.com

Contact:0086-25-83172879

Address:B12 Technology and Innovation Building, Nanjing Tech University, No.5 New Model Road
shanghai Tauto Biotech Co., Ltd

website:http://www.tautobiotech.com/en/index.htm

Contact:+86-21-51320588 ext. 8025

Address:No. 326, Aidisheng Rd , Zhangjiang Hi-tech Park, Shanghai , P.R.CHINA

Relevant to this article

Synthesis and analgesic activity of some acetamide derivatives

Doi:10.3109/14756366.2011.587417
(2012)
Catalysis of Cross-Coupling and Homocoupling Reactions of Aryl Halides Utilizing Ni(0), Ni(I), and Ni(II) Precursors; Ni(0) Compounds as the Probable Catalytic Species but Ni(I) Compounds as Intermediates and Products

Doi:10.1021/acs.organomet.7b00446
(2017)
Doi:10.1039/jr9550001834
(1955)
A NOVEL ROUTE TO SUBSTITUTED PHOSPHONATES VIA CONJUGATE ADDITION OF ORGANOMETALLICS TO 1-(FUNCTIONALLY) SUBSTITUTED ALKENE PHOSPHONATES.

Doi:10.1016/S0040-4039(01)81440-4
(1984)
Doi:10.1021/jo01110a024
(1956)
INFLUENCE OF A SILYL GROUP ON AN ALLYLIC POSITION. A THEORETICAL APPROACH

Doi:10.1016/0040-4020(80)80114-1
(1980)

Article Doi