Enzymatic Oxidation of Alkyl Sulfides by Cytochrome P-450 and Hydroxyl Radical

Article abstract of DOI:10.1246/bcsj.54.1163

The oxidation of alkyl sulfides, sulfoxides, and sulfones was examined with either rabbit liver microsomes or a reconstituted system containing purified cytochrome P-450, S-dealkylation being found to take place more readily with alkyl sulfides bearing a higher acidic α-hydrogen.Similar results were obtained in the oxidation of alkyl sulfides by hydroxyl radical.Both S-dealkylation and S-oxygenation products are presumed to be formed via the cation radical intermediate.