High affinity phenylglycinol-based NK1 receptor antagonists

DOI: 10.1016/S0960-894X(97)10163-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 51 - 56 (1998)

Update date:2022-08-03

Topics:

Authors:

Owens Owens

Harrison

Moseley Moseley

Swain Swain

Sadowski

Cascieri

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(97)10163-9

Heterocyclic replacements for the carboxamido group of the previously disclosed phenylglycinol-based human NK₁ (hNK₁) receptor antagonists have been investigated, ultimately leading to acyclic compounds with sub-nanomolar affinity for the hNK₁ receptor.

Full text of DOI:10.1016/S0960-894X(97)10163-9

Products guided by the article

Product name:2H-Tetrazole, 5-(chloromethyl)-2-methyl-

Cas No:55408-14-5

R&D Labs maybe for 55408-14-5

PharmaResources(Kaiyuan)CO,.Ltd

Contact:+86-21-50720028

Address:No.3, Beihuan Road, Economic Development District, Kaiyuan City, Tieling City, Liaoning Province, China 112300
HUNAN OUYA BIOLOGICAL CO.,LTD

Contact:+8613400661290

Address:No 908,Kangwan Rd, Liuyang Economic
SEA BRGIHT INDUSTRY CO.,LIMITED

Contact:0086 755 8622 3990

Address:Rm 17B3,GuangCaiXinTianDi Bldg,GuiMiao Rd,NanShan District,Shenzhen,China
Wuhan Shengmao Corp

website:http://www.shengmaochem.com

Contact:86-27-82853423, 82819281

Address:Rm 202, A Unit Huaqiao Building No. 2, Lihuangpi Road, Wuhan, China
puyang hongda shengdao new material co.,ltd.

Contact:+86-393- 4896278

Address:No.29 East Zhongyuan Road

Relevant to this article

Synthesis, spectral, thermal and BVS investigations on ZnS₄N^N/N coordination environment: Single crystal X-ray structures of bis(dibenzyldithiocarbamato)(N^N)Zinc(II) complexes (N^N = 1,10-phenanthroline, tetramethylethylenediamine and 4,4′-bipyridine)

Doi:10.1016/j.poly.2010.02.001
(2010)
Highly Luminescent Tetradentate Bis-Cyclometalated Platinum Complexes: Design, Synthesis, Structure, Photophysics, and Electroluminescence Application

Doi:10.1021/ic1002226
(2010)
Synthesis, structures and spectroscopic properties of platinum complexes containing orthometalated 2-phenylpyridine

Doi:10.1016/j.jorganchem.2010.01.035
(2010)
Sesquiterpene alcohols from Chamaecyparis obtusa leaf oil

Doi:10.1016/0031-9422(95)00901-9
(1996)
Methoxypyridines in the synthesis of lycopodium alkaloids: Total synthesis of (±)-lycoposerramine R

Doi:10.1021/ol100823t
(2010)
Vicarious nucleophilic amination of five-membered 4,6-dinitrobenzoheterocycles

Doi:10.1007/s11172-020-2773-z
()

Article Doi