High affinity phenylglycinol-based NK1 receptor antagonists

DOI: 10.1016/S0960-894X(97)10163-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 51 - 56 (1998)

Update date:2022-08-03

Topics:

Authors:

Owens Owens

Harrison

Moseley Moseley

Swain Swain

Sadowski

Cascieri

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Article abstract of DOI:10.1016/S0960-894X(97)10163-9

Heterocyclic replacements for the carboxamido group of the previously disclosed phenylglycinol-based human NK₁ (hNK₁) receptor antagonists have been investigated, ultimately leading to acyclic compounds with sub-nanomolar affinity for the hNK₁ receptor.

Full text of DOI:10.1016/S0960-894X(97)10163-9

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