Journal of Pharmaceutical Sciences p. 646 - 648 (1975)
Update date:2022-08-05
Topics:
Shiau
De
Harmon
A series of alkylthiocolchicines (methyl, ethyl, n butyl, n hexyl, n octyl and pinanyl) was prepared from cholchicine by treatment with the appropriate alkyl mercaptan and p toluene sulfonic acid. Some of these compounds (methyl, ethyl, and n butylthiocolchicines) were deacetylated in good yields with 2 N hydrochloric acid in methanol. These compounds were tested for their antileukemic activity in an in vitro assay against L 1210 (mouse leukemia). Preliminary results showed that methylthiocolchicine is more active and the other alkylthiocolchicines are much less active than colchicine. N deacetyl methylthiocolchicine is as active as colchicine.
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(1974)Doi:10.1055/s-1998-1883
(1998)Doi:10.1021/ja00885a031
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(2003)Doi:10.1002/jhet.5570300416
(1993)
