Solid-phase synthesis of HTLV-1 protease inhibitors containing hydroxyethylamine dipeptide isostere

DOI: 10.1021/jo030063a

Source and publish data:

Journal of Organic Chemistry p. 4755 - 4763 (2003)

Update date:2022-08-04

Topics:

Authors:

Akaji, Kenichi

Teruya, Kenta

Aimoto, Saburo

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Article abstract of DOI:10.1021/jo030063a

An efficient method has been developed for the first solid-phase synthesis of HTLV-1 protease inhibitors that contain hydroxyethylamine isostere as a transition-state mimetic. The synthetic procedure was designed to allow the evaluation of stereostructure

Full text of DOI:10.1021/jo030063a

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