Synthesis of original trifluoromethylated 6-aryl-pyridazines fused with thiazolidine or 1,2,4-triazole

Article abstract of DOI:10.1055/s-2005-918433

An efficient synthesis of original 8-trifluoromethyl-7H-thiazolo[3,2-b]-and 1,2,4-triazolo[4,3-b]pyridazines is described. Starting from the 4-trifluoromethyl-4,5-dihydropyridazin-3-one, the methodology involves a five-membered ring closure, based on the