Journal of Medicinal Chemistry p. 593 - 599 (1975)
Update date:2022-08-04
Topics:
Lednicer
Emmert
Rudzik
Graham
The preparation of butyrophenone derivatives of 4 aryl 4 (hydroxymethyl) cyclohex 1 ylamines starting from the corresponding 4 cyano 4 phenylcyclohexan 1 ones is described. Substitution was varied in both rings; both isomers of 4 phenyl 4 (hydroxymethyl)cyclohex 1 ylamine were characterized. Those derivatives which carried p fluoro substitution on the butyrophenone exhibited hypotensive activity in the rat with diminished CNS activity compared to compounds lacking the hydroxymethyl group. The effect of substitution on the 4 aryl ring is discussed.
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Doi:10.1021/jm00241a025
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(1956)Doi:10.1021/jo026797p
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(2003)Doi:10.1002/hlca.200390082
(2003)Doi:10.1016/S0040-4039(03)00442-8
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