Palladium-catalyzed cross-coupling of aryl chlorides with arylsilatranes

Article abstract of DOI:10.3987/COM-16-S(S)21

The cross-coupling reactions of arylsilatranes with readily available and inexpensive aryl chlorides were carried out in toluene/THF at 100 °C for 3 h in the presence of tetrabutylammonium fluoride as an activator for smooth transmetalation and catalytic amounts of palladium(II) acetate and XPhos.

Full text of DOI:10.3987/COM-16-S(S)21

SUPPORTING INFORMATION
PALLADIUM-CATALYZED CROSS-COUPLING OF ARYL CHLORIDES WITH
ARYLSILATRANES
Yutaro Yamamoto, Alexandre Baralle, Anaïs Godefroy, Kei Murakami, Hideki Yorimitsu,* and
Atsuhiro Osuka
Table of Contents
1H and 13C NMR Spectra in CDCl3 at Room Temperature

O
O
N Si
O
2a

O
O
N Si
OMe
O
2b

O
O
N Si
NMe2
O
2c

O
O
N Si
CF3
O
2d

O
O
N Si
O
2e

O
O
S
N Si
O
2f

O
O
S
N Si
O
2g

3a
OMe

3b
SiMe3

OMe
3c

3d
NH2

3e
CH2OH

3f
CHO

3g

3h
CF3

3i
CO2Et

3j
CN

3k
NO2

4a

4b

OMe
5a
OMe

OMe
5b
NMe2

OMe
5c
CF3

OMe
5d