Tetrahedron p. 4031 - 4038 (1990)
Update date:2022-08-05
Topics: Alkylation Regioselectivity Yield Catalyst Steric hindrance Mass spectrometry (MS) Nucleophilic substitution Nuclear Magnetic Resonance (NMR) Oxidative Addition Grignard Reagent Radical mechanism Heteroaryl Silyl group Gas chromatography (GC) Inert atmosphere Reaction quenching Organolithium compound
Epifani, Erbana
Florio, Saverio
Troisi, Luigino
Heteroaryl alkyl metals 3 undergo methylation and ethylation upon treatment with bistrimethylsilylperoxide 1a and bistriethylsilylperoxide 1b.Benzothiazolylderivatives 3c-d and 3h-j react with 1a giving trimethylsilyloxylation other than methylation products.The reaction of 3a-b with 1a leads also to the trimethylsilylation product 5.The reaction of 3g, 3c and 3k with 1b provides the ethylated derivatives 2h, 2d and 2n respectively.No reaction occurred when 3c was treated with 1c.
View MoreContact:+86-025-52406782
Address:8 Taizishan Rd., Yanjiang Industrial Development Area, Nanjing, Jiangsu, China.
Chengdu CSH Pharmaceutical Co.,ltd
Contact:+86-(28)-85321971
Address:Block B,New Hope Int. Tian Fu New District, Chengdu, Sichuan, China
Shanggao Ruiya Fine Chemicals Co., Ltd
Contact:+86-795-2592103
Address:Xingguang Nanlu,Shanggao County Industry Park
Hangzhou Neway Chemicals Co., Ltd.
Contact:+86-571-85095566
Address:Room 803, Qinglian Bldg, No 139 Qingchun Road, Hangzhou, Zhejiang China
shanghai tuomiao chemicial co.,ltd.
website:https://www.tuomiaochem.com/
Contact:021 - 59853336
Address:shanghai
Doi:10.1021/jo00830a006
(1970)Doi:10.1016/S0022-328X(03)00101-3
(2003)Doi:10.1016/S0277-5387(00)80410-6
(1988)Doi:10.1021/jo00926a011
(1974)Doi:10.1021/jo00929a008
(1974)Doi:10.1016/j.bmcl.2010.07.042
(2010)
