
Synthetic Communications p. 667 - 677 (2003)
Update date:2022-08-02
Topics:
Bieniek, Adam
Epsztajn, Jan
Kulikiewicz, Krystyna K.
A convenient two step protocol preparation of the ortho-alkylated (by secondary substituent with the carbomethoxy group at the end of alkyl chain) aromatic carboxylic acids 6 from benzoic acids anilides 1 was developed, which exploited the reductive alkylation of phthalides 4 with silyl vinyl ethers 5a-b or silyl ketene acetals 5c-g as a key step, is described.
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