Journal of Medicinal Chemistry p. 840 - 845 (1984)
Update date:2022-08-02
Topics:
Woltersdorf, O. W.
deSolms, S. J.
Stokker, G. E.
Cragoe, E. J.
Investigation of the chemistry of the potent uricosuric diuretic indacrinone (MK-196) prompted the synthesis of a series of 3-oxo derivatives, i.e., the indan-1,3-diones.In general, both pharmacological parameters (uricosuria and diuresis) were significantly less pronounced with the 1,3-diones than with the parent 1-oxo compounds
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