Journal of Medicinal Chemistry p. 2357 - 2362 (1989)
Update date:2022-08-05
Topics: Antagonist In vitro Affinity Potency Scaffold Piperidine in vivo Structure-Activity Relationship (SAR) Opioid receptor Spiro compound Probe Agonist Receptor binding assay Xanthene
Galt, Ronald H. B.
Horbury, John
Matusiak, Zbigniew S.
Pearce, Robert J.
Shaw, John S.
A series of novel 1'-methylxanthene-9-sspiro-4'-piperidines has been prepared in the search for opiate analgesics with improved pharmacological properties.It has been found that intriduction of a hydroxyl group into the 4-position of the xanthenespiropipe
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