The Xanthene-9-spiro-4'-piperidine Nucleus as a Probe for Opiate Activity

DOI: 10.1021/jm00130a022

Source and publish data:

Journal of Medicinal Chemistry p. 2357 - 2362 (1989)

Update date:2022-08-05

Topics: Antagonist In vitro Affinity Potency Scaffold Piperidine in vivo Structure-Activity Relationship (SAR) Opioid receptor Spiro compound Probe Agonist Receptor binding assay Xanthene

Authors:

Galt, Ronald H. B.

Horbury, John

Matusiak, Zbigniew S.

Pearce, Robert J.

Shaw, John S.

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Article abstract of DOI:10.1021/jm00130a022

A series of novel 1'-methylxanthene-9-sspiro-4'-piperidines has been prepared in the search for opiate analgesics with improved pharmacological properties.It has been found that intriduction of a hydroxyl group into the 4-position of the xanthenespiropipe

Full text of DOI:10.1021/jm00130a022

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