4
Tetrahedron Letters
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isothiazoline derivatives were limited with the use of
1,3,4-oxathiazol-2-one moiety, we report the synthesis of
chiral spiroindene isothiazoline heterocycles for the first
time. We have successfully separated majority of two
regioisomers from mixture by Grace column purification.
One of the regioisomeric compound 18a was purified by
chiral SFC method and confirmed two enantiomers.
Further applications of this methodology and bioactivity
study of these new heterocycles are in progress.
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Supplementary Material
The spectroscopic data (experimental procedure, 1H
NMR, 13C NMR, IR and HRMS) associated with this
article can be found in the online version.
ACKNOWLEDGMENT
Authors are grateful to GVK Biosciences Pvt. Ltd., for the
financial support and encouragement. Help from the
analytical department for the analytical data is
appreciated. We thank Dr.Sudhir Kumar Singh for his
invaluable support and motivation.
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