Bioorganic and Medicinal Chemistry Letters p. 2973 - 2978 (1997)
Update date:2022-08-04
Topics:
Westwood, Nicholas J.
Claridge, Timothy D. W.
Edwards, Philip N.
Schofield, Christopher J.
The reaction of a monocyclic γ-lactam with the serine protease elastase occurs via reversible formation of a hydrolytically labile acyl-enzyme complex; in contrast analogous β-lactam inhibitors irreversibly react to form a relatively stable acyl-enzyme complex.
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