Lewis Acid Assisted Annelation of Trimethylsilyl Enol Ethers of 1-Acetylcyclohexenes with α,β-Unsaturated Carbonyl Compounds to give Substituted 2-Decalones; Synthesis of (+/-)-ε-Cadinene

Article abstract of DOI:10.1039/c39870001333

The trimethylsilyl enol ethers of 1-acetylcyclohexenes undergo a Lewis-acid-assisted one-pot annelation reaction with α,β-unsaturated carbonyl compounds to produce 5-substituted 2-decalones; the application of this reaction has enabled a synthesis of (+/-)-ε-cadinene (12).