Identification of a non peptidic RANTES antagonist

DOI: 10.1016/S0960-894X(98)00094-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 771 - 774 (1998)

Update date:2022-07-30

Topics:

Authors:

Bright, Colin

Brown, Thomas J.

Cox, Paul

Halley, Frank

Lockey, Peter

McLay, Iain M.

Moore, Una

Porter, Barry

Williams, Robert J.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00094-8

A series of phenothiazines demonstrating inhibition of RANTES binding to THP-1 cell membranes has been identified. The lead compound RP23618 (IC₅₀ = 3 μM) was found to inhibit specific binding of ¹²⁵I-RANTES, but not ¹²⁵I-MCP-1 to THP-1 cell membranes and furthermore to antagonise RANTES, but not MCP-1-induced chemotaxis of THP-1 cells.

Full text of DOI:10.1016/S0960-894X(98)00094-8

Products guided by the article

Product name:8-(3-phenothiazin-10-yl-propyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one

Cas No:58012-09-2

R&D Labs maybe for 58012-09-2

TIANJIN GST CHEMICAL TECHNOLOGY CO., LTD

Contact:+86-22-25210964

Address:Room. 208, No. -12-C, No. 13, Xinbei Road, Tanggu District, New Haixin Area, Tianjin City, China
Phantom-pharma

Contact:

Address:
SINO Industries Company Limited(expird)

Contact:86-29-85369724

Address:No.111, Jiefang Road, Xi’an, China
shijiazhuang shuanglian chemical industry co.,ltd

Contact:0311-82190302

Address:Luquan Intersection , Shijiazhuang--Taiyuan Expressway，Shijiazhuang City
Jinan Decheng Hemu Medical Technology Co.，Ltd.

Contact:+86-531-68650525

Address:NO.554 Zhengfeng Road High-new Technology Development Zone

Relevant to this article

Synthesis of nitrido(phthalocyaninato)metal(V) complexes R_nPcMN (M = Re, Mo, W) and new compounds with nitrido-bridges between rhenium and elements of the third main group

Doi:10.1002/zaac.200390149
(2003)
Cyclic polyamidato dianions as bridges between Mo₂⁴⁺ units: Synthesis, crystal structures, electrochemistry, absorption spectra, and electronic structures

Doi:10.1021/ja0358044
(2003)
Doi:10.1021/ja01153a504
(1951)
Solvolysis of sterol tosylates in aqueous dimethylformamide

Doi:10.1007/BF02234855
(1999)
Effective Formylation of Amines with Carbon Dioxide and Diphenylsilane Catalyzed by Chelating bis(tzNHC) Rhodium Complexes

Doi:10.1002/anie.201504072
(2015)
Doi:10.1016/S0020-1693(00)91707-9
(1976)

Article Doi