Bioorganic and Medicinal Chemistry Letters p. 771 - 774 (1998)
Update date:2022-07-30
Topics:
Bright, Colin
Brown, Thomas J.
Cox, Paul
Halley, Frank
Lockey, Peter
McLay, Iain M.
Moore, Una
Porter, Barry
Williams, Robert J.
A series of phenothiazines demonstrating inhibition of RANTES binding to THP-1 cell membranes has been identified. The lead compound RP23618 (IC50 = 3 μM) was found to inhibit specific binding of 125I-RANTES, but not 125I-MCP-1 to THP-1 cell membranes and furthermore to antagonise RANTES, but not MCP-1-induced chemotaxis of THP-1 cells.
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