Identification of a non peptidic RANTES antagonist

Article abstract of DOI:10.1016/S0960-894X(98)00094-8

A series of phenothiazines demonstrating inhibition of RANTES binding to THP-1 cell membranes has been identified. The lead compound RP23618 (IC₅₀ = 3 μM) was found to inhibit specific binding of ¹²⁵I-RANTES, but not ¹²⁵I-MCP-1 to THP-1 cell membranes and furthermore to antagonise RANTES, but not MCP-1-induced chemotaxis of THP-1 cells.