Planta Medica p. 271 - 274 (1995)
Update date:2022-09-26
Topics:
Verotta
Aburjai
Rogers
Dorigo
Maragno
Fraccarollo
Santostasi
Gaion
Floreani
Carpenedo
Two alkaloids 1 and 2 were isolated from the seeds of Erythrophleum lasianthum. Their structures were assigned by spectroscopic and chemical means as 3β-hydroxynorerythrosuamine (1) and its 3-O-β-D-glucopyranoside (2). In spontaneously beating atria, both compounds 1 and 2 showed a marked and concentration-dependent positive inotropic activity and a weak negative chronotropic activity. The positive inotropic effect induced by 1 and 2 was not modified by propranolol, prazosin, carbachol, and ranitidine plus pyrilamine. Both 1 and 2 were very active in inhibiting the Na+/K+-ATPase isolated from bovine cardiac sarcolemmal vesicles.
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Doi:10.1039/DT9770002154
()Doi:10.1007/BF00473927
()Doi:10.1016/S0031-9422(00)97274-1
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