First asymmetric total synthesis of (-)-antofine by using an enantioselective catalytic phase transfer alkylation

Article abstract of DOI:10.1021/ol0349007

(Matrix presented) The first asymmetric total synthesis of a potential antitumor phenanthroindolizidine alkaloid, (-)-antofine, is described. An important feature of this synthesis is the creation of a stereogenic center by using enantioselective catalyti