Reactions of 2 acyloxyisobutyryl halides with nucleosides. VI. Synthesis and biological evaluation of some 3' acyl derivatives of 2,2' anhydro 1 (β D arabinofuranosyl)cytosine hydrochloride

DOI: 10.1021/jm00227a016

Source and publish data:

Journal of Medicinal Chemistry p. 654 - 662 (1976)

Update date:2022-08-02

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Authors:

Hamamura

Prystasz

Verheyden

Moffatt Moffatt

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Article abstract of DOI:10.1021/jm00227a016

The reactions of cytidine with 22 different 2 O acyloxyisobutyryl chlorides lead to the isolation of the corresponding 2, 2' anhydro 1 (3' O acyl β D arabinofuranosyl) cytosine hydrochlorides. These compounds, which all show cytotoxicity against HeLa cell

Full text of DOI:10.1021/jm00227a016

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