Synthesis and Biological Evaluation of 14-Alkoxymorphinans. 1. Highly Potent Opioid Agonists in the Series of (-)-14-Methoxy-N-methylmorphinan-6-ones

DOI: 10.1021/jm00378a009

Source and publish data:

Journal of Medicinal Chemistry p. 1575 - 1579 (1984)

Update date:2022-08-04

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Authors:

Schmidhammer, Helmut

Aeppli, Lislott

Atwell, Louise

Fritsch, Florian

Jacobson, Authur E.

et al. et al.

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Article abstract of DOI:10.1021/jm00378a009

A series of eight (-)-14-methylmorphinan-6-ones was synthesized and biologically evaluated.The morphinanones 3-7 were prepared from 3-desoxy-7,8-dihydro-14-hydroxymorphinone (1).The key step in this synthetic sequence, O-methylation in position 14, was ac

Full text of DOI:10.1021/jm00378a009

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Product name:(-)-3-(benzyloxy)-4,5-epoxy-14-hydroxy-N-methylmorphinan-6-one

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