Tetrahedron Letters p. 5051 - 5054 (1980)
Update date:2022-07-29
Topics:
Knght, David W.
Nott, Andrew P.
Dianions (3) and (6) can be generated in high yield from the corresponding thiophencarboxylic acids with lithium diisopropylamide and react with a number of representative electrophiles to give fair to good yields of 5-substituted-thiophen-2-carboxylic acids and 2-substituted thiophen-3-carboxylic acids respectively.
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