Synthesis and microbiological evaluation of novel [N-acetyl-2,6- diarylpiperidin-4-yl]-5-spiro-4-acetyl-2-(acetylamino)-Δ2-1,3, 4-thiadiazolines

DOI: 10.1007/s00044-004-0035-5

Source and publish data:

Medicinal Chemistry Research p. 297 - 311 (2004)

Update date:2022-08-02

Topics:

Authors:

Balasubramanian

Ramalingan

Aridoss Aridoss

Parthiban

Kabilan Kabilan

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Article abstract of DOI:10.1007/s00044-004-0035-5

Some novel spiropiperidinyl thiadiazolines have been synthesized and their bacterial activity against Streptococcus faecalis, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Klepsiella pneumoniae and antifungal activity against Cryptococcus neoformans, Candida-6, Candida-51, Aspergillus niger and Aspergillus flavus were evaluated. Compound 23 exhibited potent antibacterial activity in vitro against Klepsiella pneumoniae while compound 24 exerted potent antifungal activity in vitro against Cryptococcus neoformans. Birkhaeuser Boston 2004.

Full text of DOI:10.1007/s00044-004-0035-5

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