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10. Payton, M.; Gifford, C.; Schartau, P.; Hagemeier, C.;
Acknowledgements
Mushtaq, A.; Lucas, S.; Pinter, K.; Sim, E. Microbiology 2001,
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The authors wish to thank the MRC for a studentship
(E.W.B.), the MRC and EPSRC for a Discipline-Hop-
per Award (R.J.V.), the Blaschko Foundation for a
Fellowship (F.P.) and the Wellcome Trust for financial
support (E.S.).
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2002, 14, 155. (b) Smith, A. Nat. Rev. Drug Disc. 2002, 1, 95.
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17. Data not shown.
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19. All compounds gave satisfactory spectroscopic data.
Complete synthetic protocols and spectroscopic data will be
reported elsewhere in a full paper.
20. Spectroscopic data for 20: mp 175–177 ꢀC; IR (KBr)
cmÀ1: 1743 (C¼O), 1708 (C¼O), 1340 (SO2sym), 1167 (SO2asym);
1H NMR (CDCl3) 400 MHz d, ppm 4.14 (s, 2H, endocyclic
CH2), 4.95 (s, 2H, ArCH2N), 7.28–8.02 (m, 13H, unresolved
Ar); 13C NMR (CDCl3) 100 MHz, d 52.3, 53.9, 125.2, 127.0,
127.5, 128.2, 128.8, 130.0, 131.1, 131.1, 132.5, 132.7, 133.0,
138.0, 138.6, 140.4, 164.7, 166.1; HRMS (ESI) (MÀH)À
C24H17N2O4S2 requires 461.0637, observed 461.0630.
21. Riddles, P. W.; Blakeley, R. L.; Zerner, B. Methods
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