Pyridoxal phosphate. 5. 2 formylethynylphosphonic acid and 2 formylethylphosphonic acid, potent inhibitors of pyridoxal phosphate binding and probes of enzyme topography

Article abstract of DOI:10.1021/jm00234a003

The title compounds were prepared in good yield by synthesis of the phosphonate diester acetals, deesterification with chloro or bromotrimethylsilane, hydrolysis of the acetal group, and formation of the characterized barium salts. The 3 carbon aldehydoph