A new asymmetric synthesis of 2,6-cis-disubstituted 4-methylenepiperidines: Total synthesis of (+)-alkaloid 241D and (+)-isosolenopsin A

Article abstract of DOI:10.1016/j.tetasy.2005.01.018

A highly diastereoselective synthesis of 2,6-cis-disubstituted-4- methylenepiperidines based on a Mannich type intramolecular cyclization of an allylsilane on an iminium ion is described. The synthetic potential of this methodology is demonstrated by the