SYNTHESIS ODS PERFLUOROCHEMICALS FOR USE AS BLOOD SUBSTITUTES. PART IV. ALACTROCHEMICAL FLUORINATION OF N-CYCLOALKYL-PYRROLIDINES AND -PIPERIDINES

Article abstract of DOI:10.1016/S0022-1139(00)81637-1

Electrochemical fluorination of N-cyclopentylpyrrolidine gave the corresponding F-amine together with a ring-opened compound N-(F-pentyl)-F-pyrrolidine in the ratio of 1 to 1, in 55 percent yield.N-cyclohexylpyrrolidine, N-cyclopentylpiperidine and N-cyclohexylpiperidine were also electrochemically fluorinated in the same manner to give the corresponding F-amines, their isomers with rearranged structures, and ring-opened ones, in the ratio of ca. 4:2:1, 2:1:1, and 2:1:1, respectively in 51 to 53 percent yields.Supporting spectral data are presented.