Tetrahedron Letters p. 6269 - 6272 (2003)
Update date:2022-08-03
Topics:
Cainelli, Gianfranco
Giacomini, Daria
Gazzano, Massimo
Galletti, Paola
Quintavalla, Arianna
This paper describes the different reactivity of E- and Z-4-alkylidene-β-lactams in acylation reactions under basic conditions. The E isomer is readily acylated, whereas the Z reacted sluggishly rearranging to the corresponding oxazin-6-one. The N-acylation of Z isomers was successfully obtained with oxalyl- or malonyl chlorides in benzene at reflux.
View MoreSHANDONG QINGYUNCHANGXIN CHEMICAL SCIENCE-TECH CO.,LTD
Contact:86-21-60560171
Address:1689Donghuan Rade,Qingyun County, Dezhou City, Shandong,China
Puyang Huicheng Electronic Material Co., Ltd
website:http://huichengchem.weba.testwebsite.cn/index_en.html
Contact:+86-393-8910800
Address:West Section Shengli Road, Puyang457000, China
Contact:86-311-83160559
Address:shijiazhuang
Shanghai Bosman Industrial Co., Ltd
Contact:86-21-63065878-8006
Address:Rm907, No.1611, North Sichuan Road, Hongkou District, Shanghai, 200080 China
Nanjing Norris Pharm Technology Co., Ltd.
Contact:+86-13901585132
Address:2 Qiande Road, Jiangning sciencepark Hi-Tech Zone, Nanjing, P.R.China
Doi:10.1002/jlcr.2580120213
(1976)Doi:10.1021/om900448j
(2009)Doi:10.1016/S0008-6215(00)80080-4
(1969)Doi:10.1021/ja01236a040
(1944)Doi:10.1039/C39760000586
(1976)Doi:10.1002/ardp.200390000
(2003)
