Journal of Medicinal Chemistry p. 469 - 474 (1980)
Update date:2022-08-04
Topics:
Bodor
Kaminski
Selk
Strategies for the design of safer drugs are discussed. The various classes of 'soft drugs' are designed to avoid undesired metabolic disposition (primarily various oxidative routes, occurring via possible toxic intermediates) and to be metabolized by a predictable manner with controlled rates. As a first example for the 'soft analogue' type drugs, a new class of antimicrobial, surface-active quaternary salts of the type RCOOCHR1-N+←X- was developed. These 'soft' quaternary salts are isosteric analogues of known 'hard' quaternary surfactants and are characterized by predictable and controllable cleavage (metabolism) to nontoxic components, while showing good activity against a wide range of bacteria. Due to their soft nature (low toxicity), the new antimicrobials are much safer than the conventional, hard analogues.
View MoreTianjin Crest Pharmaceutical R&D Co., Ltd. (Tianjin Yao Technology Development Co., Ltd.)(expird)
Contact:+86-22-66211386
Address:Building B5-405, No, 80 4th Avenue, TEDA, Tianjin, China P.R. 300457
Changzhou naidechemical Co.Ltd
Contact:+86-519-82589807
Address:NO.25,Houyang street,Jintan,Changzhou City
Lanling Hongchuang Flame Retardant Co., Ltd.
Contact:+86-531-68858132
Address:East Huafeichang Road, Cangshan County, Linyi, Shandong, China (Mainland)
Anhui Sholon New Material Technology Co., Ltd.
website:http://www.sholonchem.com
Contact:+86-550-5261666
Address:4/F Block B, Beijing Chemical Building.No.520 Tianrun Road ,Science & Education Town Wujin District, Changzhou City Jiangsu Province
Xi'an North Information Industry Co., Ltd. Weilv Chemical Department
Contact:+86-29-88156413
Address:Jixiang Road 99 Xi'an Shaanxi Province
Doi:10.1016/S0960-894X(03)00659-0
(2003)Doi:10.1007/BF00480398
()Doi:10.1016/S0040-4039(00)92072-0
(1992)Doi:10.1021/ja00509a046
(1979)Doi:10.1021/jo00430a007
(1977)Doi:10.1016/j.freeradbiomed.2016.04.196
(2016)