Novel solid phase synthesis of 2′-o-methylribonucleoside 5′-triphosphates and their α-thio analogues

Article abstract of DOI:10.1016/S0040-4039(00)92072-0

Simple, versatile and convenient syntheses of 2′0-methylribonucleoside 5-triphosphates have been accomplished on controlled pore glass (CPG) in good yield (60%) using 2-chloro-4H-1,3,2-benzhodioxaphosphorin-4-one (salicyl phosphorochloridite). Moderate yields were obtained for the corresponding α-thiotri-phosphates.