General approach for the synthesis of macroline/sarpagine related indole alkaloids via the asymmetric Pictet-Spengler reaction: The enantiospecific synthesis of (-)-anhydromacrosalhine-methine

Article abstract of DOI:10.1016/0040-4039(96)01009-X

An enantiospecific total synthesis of (-)-anhydromacrosalhine-methine 3a has been accomplished from D-(+)-tryptophan via the asymmetric Pictet- Spengler reaction. A partial synthesis of 3a from the natural product (+)- ajmaline has also been completed.